Kaposi’s Sarcoma and Kaposi’s Sarcoma-associated Herpesvirus/Human Herpesvirus 8: An Overview
نویسندگان
چکیده
Kaposi’s sarcoma (KS) is a vascular tumor that was brought to the attention of the medical community over a century ago in a fascinating case series in which purple-coloured nodular skin lesions were observed on five elderly men, with widespread cutaneous and visceral involvement reported in one patient at autopsy (Kaposi, 1872 as cited in Ober, 1988). This ‘Classic’ variant of KS is rare and the majority of cases are found in elderly Mediterranean men and Jewish people born in Eastern Europe (Rothman, 1962). Large-scale epidemiological studies have highlighted three other variants of KS; ‘African’ or ‘Endemic’ KS in young black adults and children in equatorial Africa (Davies and Lothe, 1962; Oettle, 1962); ‘Iatrogenic’ or ‘Posttransplant’ KS in patients who have previously received immunosuppressive therapy or in those who are organ transplant recipients (Klepp et al., 1978; Harwood et al., 1979; Penn, 1979); and ‘AIDS(-related)’ or ‘Epidemic’ KS, first noted in immunocompromised homosexual men from New York and California (Friedman-Kien et al., 1981). All four forms of KS have a predilection for males and the male:female ratio ranges from 2.3:1 in Iatrogenic KS to 106:1 in Epidemic KS and the clinical course of Epidemic/AIDS-KS is more aggressive (Friedman-Kien and Saltzman, 1990). The strikingly unusual pattern of KS distribution begs the question as to what features, if any, are common to the four epidemiological variants of KS.
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REPORTS Expression of Human Herpesvirus 8-Encoded Cyclin D in Kaposi’s Sarcoma Spindle Cells
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متن کاملDetection of human herpesvirus-6 DNA in bone marrow biopsies from patients with multiple myeloma and Waldenstrom’s macroglobulin-
patients with multiple myeloma and Waldenstrom’s macroglobulinemia. Blood 91:4393, 1998 15. Brousset P, Meggetto F, Attal M, Delsol G: Kaposi’s sarcomaassociated herpesvirus infection and multiple myeloma. Science 278: 1972, 1997 16. Beksac M, Ma M, DerDanielian M, Zhang L, Liu J, Kuzu I, Erekul S, Vescio R, Berenson J: Frequent demonstration of human nerpesvirus 8 (HHV-8) in bone marrow sample...
متن کاملDetection of human herpesvirus-6 DNA in bone marrow biopsies from patients with multiple myeloma and Waldenstrom’s macroglobulin-
patients with multiple myeloma and Waldenstrom’s macroglobulinemia. Blood 91:4393, 1998 15. Brousset P, Meggetto F, Attal M, Delsol G: Kaposi’s sarcomaassociated herpesvirus infection and multiple myeloma. Science 278: 1972, 1997 16. Beksac M, Ma M, DerDanielian M, Zhang L, Liu J, Kuzu I, Erekul S, Vescio R, Berenson J: Frequent demonstration of human nerpesvirus 8 (HHV-8) in bone marrow sample...
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